Coronavirus Related News

Super Computer modelling shows new antiviral drug effective in treating Coronavirus: Australian researchers

Endmedia health press

A super computer modelling has proved that the new anti-viral drug is effective in blocking the Coronavirus.

Researchers from the University of Monash in Australia showed thorough modelling of the Alpha ketoamide 13b on the super computer, it found it has the potential to stop the duplication of the Coronavirus

Monash University senior research fellow Tom Karagiannis told Xinhua that alpha-ketoamide 13b bound tightly to the active site of the viral main protease, which is responsible for cleaving viral proteins inside cells.

“By blocking the active site of the protease with alpha-ketoamide 13b you can inhibit viral replication,” Karagiannis explained.

“The modelling showed that the binding was stable for prolonged simulation times.”

Alpha-ketoamide 13b is a new and improved compound based on ketoamide compounds investigated by Professor Rolf Hilgenfeld’s team in Germany following the SARS outbreak in 2003.

“This particular compound has improved qualities for administration to humans,” Karagiannis said.

Karagiannis said German researchers have already shown alpha-ketoamide works in cell culture and there is hope that it may be effective by inhalation.

Meanwhile, Karagiannis and his team will keep on verifying promising new drugs.

Source: Xinhua Sydney
The research paper has been published in the Computational ­Biology Chemistry Journal.

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